According to the man(8) page, it will avoid touching any blocks that have the chattr -f flag set, which is XSR_XFLAGS_NODEFRAG... So I think if the docs are still accurate to the code, yes.
That's because the drive was written to its limits; the defrag runs a TRIM command that safely releases and resets empty sectors. Random reads and sequential reads /on clean drives that are regularly TRIMmed/ are within random variance of each other.
Source: ran large scale data collection for a data centre when SSDs were relatively new to the company so focused a lot on it, plus lots of data from various sectors since.