New Class of Antibiotics Proves Potent Against Multi-Drug Resistant Bacteria ( scitechdaily.com )
This study describes the identification of an antibiotic class acting via LpxH, involved in lipopolysaccharide synthesis having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Further development of this class of antibiotics could make an important contribution to the ongoing struggle against antibiotic resistance.
https://www.pnas.org/doi/10.1073/pnas.2317274121 (open access)
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