@veroalgoz@actuallyautustic@actuallyautistic@actuallyadhd I was diagnosed as AuDHD a few years after my Myalgic Encephalomyelitis (ME) diagnosis so I'm a little complicated, but generally I react strongly to very small doses of most medicines but there are a couple that I've needed much higher doses than average to get the same effect.
Up until I read this post I presumed it was due to ME, but you're absolutely right in that it could be ADHD or Autism (or a combination of everything) having the effect.
I can only tolerate 1.25mg Methylphenidate at a time, but I can occasionally take 5mg a day (4 x 1.5mg 2 hours apart) but due to ME I get significant PEM payback when I do.
I tried numerous antidepressants for ME and they all gave me horrid side-effects, and did very little to nothing at all for my symptoms regardless of the dose I took. I tried St John's Wort as a tea after this and it worked brilliantly for anxiety with zero side-effects.
I struggle with analgesia and purposefully take small doses irregularly so they keep working, but honestly really need large doses.
I take medicinal cannabis and my doctor is amazed at how little I take, but I don't like the "high" and take just enough to not get "high". I had used cannabis a handful of times prior to getting ME and actually required large doses to get high despite not being a regular consumer.