Baby-Transfem here, started HRT literally last week:
Until last friday I was suicidal, constantly depressed and full of self-hate I couldn't understand.
Since I got my first dose estrogen my mental health drastically improved (as did some other hormone-related body functions that only need the hormones in my blood but not necessarily a prolonged exposure).
I learned from my doc that some transpersons have a brain structure of their non-assigned sex and then show exactly my pattern of relief; meaning my brain was actually born to be estrogen- instead of testosterone-dominated.
(which seems to be based on the hormones oned mom exposed one during 3-4th and 10-14th week of infancy. One periods influences the gender of the brain, the other the sex of the general body)
So while I see where you are coming from, and I heavily prepare myself for all the sexism that will probably bring me back to earth as soon as I visually feminize; I can attest that HRT improved both drastically for me (for now)