If you mean on the Threadiverse in particular, one of the larger home instances, lemmy.blahaj.zone, is aimed at the trans crowd, was one of the older active instances that I recall.
EDIT: One of the first discussions I recall being in on the Threadiverse was when kbin.social -- which puts random comments in the sidebar to help people discover new communities -- sent both me and apparently some other guy, both using kbin.social, to a discussion in !technology. He had an upset comment about how everyone in the thread was furry.
EDIT2: And I don't see that community any more, so I wonder if they closed it down.
EDIT3: I remember when I was trying to find new communities a while back, was looking for interesting tech stuff. I see !unixsocks, figure ah hah, Unix socket development forum. I like a good chat about network development! No, it's...unexpectedly trans Unix sysadmins posing with their Unix system in feminine stockings. Ah, well.