At home alone I wear exactly one thing, sweatpants and an exquisitely soft long sleeve tunic blouse. I wash it about once a week.
One time the person who had the washing machine before me had used some kind of horrible scented detergent and my beloved safe, comfortable house clothes picked up not only an unbearable smell but some kind of chemical residue that made it itchy and miserable. I washed it maybe a dozen times and nothing could restore it.
The story has a happy ending, I was able to get the exact same item and only had a short adjustment period for the new one. But I also bought a spare, just in case.