onlinepersona ,

Sure you can. As others have said, a list comprehension returns a new list. See the documentation.

What are you trying to do though? Append a list comprehension to an existing list?

See a modified version of @eager_eagle's code from their comment.

def double(x):
  return 2 * x
a = list(range(10))
a.extend(double(value) for value in range(5))

# a has 15 elements
print(a)

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