This is the answer. I've had a 256gb SSD with nothing but Windows on it since 2018. Every time Windows starts to get a little feisty (far too often.. sigh..) I just nuke the drive from orbit and spend an hour reinstalling windows rather than spending a weekend or two shuffling things around to get back to where they need to be.
Only thing that's mildly annoying is most things expect everything to be on the C drive by default and it can be a little annoying navigating programs that don't "remember" the last folder they looked in. But telling the boys that you have to reinstall Windows and then being back on for games the same day, definitely worth it.