I once played a post-Atlantean vampire who lived in the PNW, taught ancient history (night classes,) and liked to draw. She also didn't believe in killing any more. She had a lot of back story and a bad accent in every language. She also had a cracked sense of humor and was only mostly sane.
I had an idea for a vampire story the other night. So you know how vampires are mysterious, partially because they're hundreds of years old, from bygone eras? Make a vampire story where the vampire is hundreds of years old, but it's hundreds of years in the future, and he was turned during the 1990's. He wears like Nirvana shirts, and ripped up jeans, and everyone thinks it is so mysterious and strange.